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Tirzepatide : Dual receptor agonist targeting GIP and GLP1 only
To examine this phenomenon more closely, we divided the feeding behavior into 3 stages (initial, middle, and final) and observed a gradually diminishing inhibitory response from the initial to the final stage (Figure 4, K and L)
The gastric emptying effect may diminish somewhat over time with continued treatment (tachyphylaxis)
Nausea is most pronounced during the first few weeks of treatment or following dose increases
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